I have one and I'm loving it. Had to do a factory reset a couple of times due to an app starting the encryption process without my consent (apparently I'd interrupted it before it was complete) but other than that it's been excellent.
I've heard about the Wi-Fi issues that people have complained about but I haven't noticed any such issues. Rumour has it that ASUS is going to fix the GPS issues with a free GPS dongle so I'll be on the lookout for that.
Desktop:
ASUS P8Z68-V PRO (BIOS version 3402) | Core i5 2500K @ 4GHz | 4GB GSkill Ripjaws F3-12800CL8D-4GBRM (2x2GB) | Palit GTX 680 Jetstream 2GB | ASUS Xonar D2X | WD 1TB HDD (WD1002FAEX) | LG CH10LS20 (Blu-ray/DVD-RW combo drive) | Corsair HX650 | Samsung 2333SW @ 1920x1080 | Windows 7 Ultimate x64 SP1 | Logitech G19 | Logitech G500
Laptop:
ASUS G73JH (Core i7 720QM, 8GB RAM, Mobility Radeon HD5870, 2x500GB HDD, 17.3" @ 1920x1080)