I decided that I would update from the BETA version of the tool, which I have not used in some time to the current (22.214.171.124) as I wanted to get a little more performance. Everything works perfectly fine apart from when I type in any number for the GPU or Memory clock and press accept it reverts to its default.
The Voltage and Fan settings works fine, and with the BETA version I could change everything. Before I revert back to the older version I wanted to see if there was something im missing or perhaps an old setting file that is causing issues (can't find any did a thorough uninstall).
On a side note the 'S' and 'G' profiles do the same thing if I click them, for a second they change the values then it reverts back to default. I don't like having to use old drivers/software versions if I can.
Asus Rampage II MOBO
2x Nvidia Geforce 480 GTX (Not Asus)
(I don't know if you require any other information, feel free to ask for it)