CPU_FAN is best for cpu cooling fans, it allows the best range of operating conditions and is configurable.
CPU_OPT is only a 12v fan header, no configuration can be done (i.e. slow down the fan connected to it).
Don't use the 3rd header that is not labeled.... >>>>
http://rog.asus.com/forum/showthread.php?14692-What-is-the-3-pin-header-to-the-right-of-the-CPU-and-...
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