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To conclude this thread, I'll add some more information (hopefully it will be useful to other people too).

As you can see I kept the iGPU disabled, as when enabled, the overclock became unstable...

I managed to pass a 25 hour stress test with Prime95 (Blend mode), increasing the VCCIO by one step, changing from Auto (1.2500V) to 1.2625V.

I think if I pass the stress tests with prime95 i can be pretty sure my system is stable.

Specs:

CPU: i7-7700k @ 4.20 GHz (Turbo boost: 4.5GHz) [delidded]
Mobo: Asus Maximus IX Extreme
GPU: Gigabyte - GTX 1080 Ti Waterforce WB Xtreme Edition 11G
RAM: 32GB - G.Skill - Trident Z...