The Sonic Studio Effect does not apply to sound coming from Spotify, every other application (that i know of) works just fine with the applied Bass and Treble boost. Why is this? Is there anyone else that has this same problem?

The way i can tell is by enabling the "Reverb" and then playing a song on Spotify and the same one on YouTube and hearing if the Reverb is there or not, as it is very easy to hear the difference with and without.

Using the Maximus X Hero with the latest BIOS (V 1003).