This has happened to me 2 times so far (when i switched to Extend monitor). The only way to fix this was to turn off the pc with power button and turn it on again. Any other solution about this?
I have the same flickering issue. I believe it has to do with Nvidia Optimus. If you uninstall the Nvidia driver it does not flicker until windows 10 reinstalls the driver. I used a clean install windows with just "Microsoft Basic Drivers" and it does not flicker for me. I havent had the issue with G-Sync mode yet. The internal display mux may have an issue.
Edit: Install the Intel Chipset driver from Asus support site. It help a lot with the issue.