Under Playback Devices, you can choose which output device you want to use by default. Using USB headsets will not disable other audio devices.
If you use analog 3.5mm then you can enhance the audio in games with Sonic Studio (bundled with your ASUS/ROG motherboard) or emulate a virtual surround environment with HRTF.
With USB, it's possible to have true surround sound with more than 2 drivers in the headset.
Sonic Studio enhancements for your motherboard audio will not work with USB audio devices. ROG headsets will have their own versions of Sonic Studio.
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FPS, Racing, and VR Gamer / Tech Enthusiast / ROG Admin