One of the most difficult stability tests any system can pass is one that does not involve a stress test. It is simply resuming or waking from sleep with a large amount of memory stored. I recall doing clunky testing when building systems for folks that went a bit like this.

Open more than 50x chrome web browser tabs. Lots of memory resource there.
Open word document of about 20mb in size with a mixture of graphics embedded and text copy that to clip board
Have a 1080p movie playing
A virus scan going

And then sleep the system.

Leave 24 hours and wake.

Man alive you would be surprised the number of times systems that had passed hours of stability testing programs failed.



OP it sounds like there is a bit of corrupted code someplace between your Firmware/Bios/OS. If you have not done so already, download again the latest bios which should also contain the latest firmware and use the BIOS to flash.

Do make note of your BIOS settings so that you can easily get your system back to where you like it.

Should sort that issue out if it is what I suspect it to be.

It seems to me like Asus does not like sleep these days. I have physically press the reset button to bring the pc back to life if it went into sleep.

Sleep issues. The desktops dont seem to like it. Had similar issues on every build Ive done over the last few years.
Disable sleep, hibernate and fast startup. Let me guess, you just select save and exit, get the prompt you didn't do anything and it starts no worries? For some reason the hiberfil.sys doesnt recover from PCIE SSDs. I verified this by running off of a SATA SSD and it never happened, go back to fresh install on NVME and its just a matter of time. Sometimes you can get it to work for awhile then an update comes through and its back to finding it in the BIOS screen.