I love questions like these.
🙂 I have been using my RVE10 for a couple years now and I love the board. It has everything I need for my gaming and production, tons of features and usability, plus lots of connectivity which I make use of, and supports an M.2. I always look for an opportunity to upgrade. However the only reason I would do it today would be to upgrade to a newer Intel i9 CPU and to make use of the newer GPU's out there too. I haven't had any single compelling reason to make those upgrades yet however, simply because of the great performance I get out of this board. That said, I don't see your suggestion above as an upgrade but closer to a parallel move. If you were to change, why not upgrade to next generation and get off the X99 platform and go to X299?
Davemon50