Make sure you're connecting to the correct header on the mobo. It has to be the 5V addressable header, not the Aura header. It could be confused. Also, are you switching control correctly from the remote to the mobo using the ON button? I assume you have it powered correctly at the hub, and you are using the correct fans per the manual?
Which mobo do you have? Maximus X
what?
Davemon50