Which NVMe spot on the motherboard are your trying to put it in ?
What BIOS are you running ?

So the MP500 is what used to be in there, and you put the Lexar NM610 M.2 2280 NVMe SSD in to that position, correct ?

That img just a reference
first time i used Lexar NM610 M.2 2280 NVMe SSD

Here is the procedure for install of windows on a new NVMe drive.

Enter BIOS, Advanced mode,

1 - Make sure you unplug all SATA and USB drives, the M.2 drive has to be the only drive installed.
2 - Go into the bios, under the boot tab there is an option for CSM, make sure it is disabled.
3 - Click on secure boot option below and make sure it is set to other OS, Not windows UEFI.
4 - Click on key management and clear secure boot keys.
5 - Insert a USB memory stick with a UEFI bootable iso of Windows 10 on it.
6 - Press F10 to save, exit and reboot.
7 - Windows will now start installing to your NVME drive as it has its own NVME driver built in.
8 - When the PC reboots hit F2 to go back into the BIOS, you will see under boot priority that windows boot manager now lists your NVME drive.
9 - Click on secure boot again but now set it to Windows UEFI mode.
10 - Click on key management and install default secure boot keys
11 - Press F10 to save and exit and windows will finish the install.

Hope you find this helpful.




PS - To be Windows 11 ready do this after the above,

Enter BIOS, Advanced mode.

Navigate to
Advanced Menu -> AMD fTPM Configuartion
TPM Device Selection: Firmware TPM

Save & Exit