I don’t use onboard sound myself. Wouldn’t think it would harm anything to uninstall those. I don’t have any of the programs you mentioned installed on my machine and I’m experiencing no issues. I’m using a creative sound blaster X4 and it works great with the creative app.
MZ790A Bios 2002, GSkill F5-8000J3848H16GX2-TZRK, 13900KS, EKWB D5 TBE 300, Seasonic Prime TX-1600 ATX 3.0, Asus Strix 4090 w/ Optimus block, Phanteks Enthoo Elite, Asus Claymore 2, Asus Gladius 3, Asus XG349C, Samsung 990, Windows 11 Pro