I will speak from my experience:
Asus Formula
12900ks
32Gb 6200 - running at 6400
RTX3090
3 Nvme x 1Tb
I am using 1 Nvme on M.1 slot for Win11 and 2 Nvme on hyper M2 card board (same brand, same model and same capacity - usind 3th. PCIE)
Running everything smoothly