I have the same problem. I've used GPU Tweak 2 before and I quit using it because of multiple problems. I decided to try it again hoping it would improve. I used it all day yesterday. I changed the settings to start with Windows, changed the OSD to show everything except the CPU info, changed the GPU clock, the memory clock and power settings to approximate my settings in AMD Settings. I benchmarked it and saved three profiles. When I ran the benchmark, all of the OSD options that I added were showing zeros, except the FPS and a voltage setting. The options screen went blank, except for check mark boxes. The benchmark itself worked great with the new settings. After I saved the three profiles, I was making some changes and when I hit Apply the screen went blank. I waited for it to recover and it never did. I tried pressing Ctrl+Alt+Delete and nothing happened. I had to turn off my computer and manually restart it. GPU Tweak 2 did not start like it was supposed to. When I opened GPU Tweak 2 again, the adjustments were there, but there was no text. There were no profiles at all. After a minute or so the screen went blank again and never recovered. This is unusable now! What is the problem? I would like to get this working! Please help!
I have GPU Tweak II Version 2072. I have a ASUS Radeon R9 390X DirectX 12 STRIX-R9390X-DC3OC-8GD5-GAMING 8GB 512-Bit GDDR5 PCI Express 3.0 HDCP Ready Video Card. I am on Windows 7 Ultimate. I have been using only AMD Settings to adjust my settings. I did set compatibility mode to Windows 7 and to Run as Administrator on GPU Tweak 2.
Thanks for your help!