Looks like there is 16 bios versions for the M4E - which of the 16 versions you are running now, might help to troubleshoot ...
... might be worth re-flashing to a different version ??
If you do return the board for service - return the board only, just as you originally received it; remove the CPU, RAM, ect ... ...
- M4EZ - 1: 3510 - 2: 1004 / i7-2600K / Redline 2133 16GB / Win7 Pro x64
- v.3510 / 8.0.0.1351 - v.8.1.0.1263 / 10.8.0.1303 - v.11.2.0.1006
- RevoDrive3x2 240GB - OS / Vector 256GB x2 RAID0 - OS / Vertex3 MI 120GB - OS / P'9230 3.0 2TB - B/U
- 9260-8i BBU - CacheCade Pro Vertex3 120GBx2 RAID0 SSD Caching - Const ES SAS RAID10 GHS - Data
- GTX580 3GB HC2 / Xonar Essence STX / ST1200G / TJ10B-W / ZR30w / SP 2500 2.1
- Water: Swiftech/Koolance/Tygon/EVGA/MIPS - Wind: SST/Noctua/Cougar