PCIe spread spectrum should be off for BCLK overclocking. But not cause of voltage spikes as that forum post suggests.
It's the modulation of the frequency in order to avoid EMI that can cause instability, it has nothing to do with voltage or the CPU.
BCLK overclocking has a very tight headroom. Most systems on this platform can't handle more than 6% increase on BCLK and when operating at the edge you probably also have to tweak skew settings as well to stabilize it. So when you're at 105 you're close to the upper end of the threshold. A slight variation in frequency can throw the system off:)
Be careful with BCLK though as you can also very easily corrupt windows installations/your data, always backup any data you would mind missing before tweaking BCLK. (I personally only suggest BCLK overclocking for benching...unless of course you know what you're doing:))
Similarly CPU spread spectrum can throw a fragile CPU overclock into instability as well (for the same reason) but generally the CPU is much more lenient than the bus..
EDIT: Btw since your RAM is not stable at 2133 with 100 strap, can you give us some more details? What RAM is it and how are you setting it up? (XMP? what timings? etc)