try this and see if it works fist close gpu tweak the open task manager and select 3d_enable.exe and then click on end task then look and see if there is gpu teak running in there and kill it if it is. then download revo uninstaller if you don't have it and use it to uninstall gpu tweak and remove all leftover stuff then reboot. now install gpu tweak again and see if it works.
amd ryzen 9 3950x
CROSSHAIR Viii hero
Corsair Hydro Series H115i
G.SKILL Trident Z 3200mhz 64gb 4x16 timings 16,18,18,38
asus rog strix gtx 1080
TOSHIBA 3TB hdd 3x a total of 9tb, 10 tb hdd and a 1tb mushkin ssd
corsair axi 1200i 1200 watt psu
thermal take view 71 case