R5E is an expensive board. For the amount of money, it has to work as prescribed in the manual. I am surprised with people accepting defects just because the other features are working O.K.
Please consider the board's very complex multilayer design and how many features were accommodated there. All elements of the design are impacting each other. If something goes wrong in one area, there is a high probability that it will change how the associated parts work.
Also, if you put together a system comprising of non defective components, the system should work fine with the automatic settings and without a need of the manual adjustments.
This is, after all, an overclockers' board and should be robust enough to withstand quite a bit of stress. If an element of the board is becoming defective only after a few weeks of use, it tells about the manufacturing quality.