Hi Toodeep, and welcome
Regardless of the "all one kit" dogma, which has merit when overclocking and using XMP in the same IMC channel, this sort of failure isn't of that sort. The dual IMCs of any CPU that runs on the R4E make a good separation between channels A/B and C/D. Of course, an ASUS employee has to talk about guarantees. The remaining possibilities are bad memory DIMMs, a bad CPU or socket difficulties.
What CPU are you using? The memories are driven directly from the CPU with relatively little influence from the motherboard. Those influences would be things like scratches in the surface of the board that could break a trace.
If you have errors on C/D, do they persist in the same channels when the memory sticks are switched around? Does the error follow particular DIMMs in other sockets? I suggest trying good DIMMs (now in A/B) in the C/D slots and suspect DIMMs from C/D in the working A/B channels. That will help isolate between DIMMS and the other probable causes.
An abnormal condition where the memories and their type are detected can be caused by bad pin connections. I have had that happen due to two causes on an R4E. Both led to data/address errors where the SPD identity data could still be read.
1. CPU socket pins are missing the contacts on the bottom of the CPU. That happened to me once because the cooler was screwed down to tight. The suggestion is to remove the CPU cooler and the CPU. Check the socket pins to be sure none are bent out of line. When replacing the cooler, be sure to tighten it evenly and snugly, but not too much.
2. You have surely noticed that the keying in channels A/B is the opposite of that in channels C/D. The DIMMS have to be turned around on one side of the CPU compared to the other side. If anyone ever tried to push DIMMs into the socket the wrong way round, the DIMMs could be damaged. I got two kits of 2 DIMMs and used them in my R4E. Two of them behaved the way you describe - recognized but abnormal. There were smashed or dented places on the contact edge of those two DIMMs. The damage caused short circuits to the adjacent pins. After a little trimming with a fine knife, the shorts were removed. Luckily there was not too much cut away and the repaired pins make good contact. The suggestion is to examine the suspect DIMMs for damage from being forced into a socket without first aligning the keys.
Hope some of this helps
Jeff