I don't have any usb issues with my peripherals so its entirely possible that it's a driver issue. If your mouse is the only item misbehaving then it could be the problem. Have you tried another mouse to see if it also behaves the same way? Also are you running the windows 10 1511 fall update or the original version? The 1511 update addresses several issues and you can get it via WU or directly using the media creation tool.
Shakerip what fastboot issue are you referring to? I've had issues with it in the past causing issues so I run with it disabled ATM. I would like to speed up the boot process as much as possible so I would like to run with it enabled.
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