I installed all the ASUS software that came with my Motherboard, figured these guys were the specialists!
However I use Vent a lot, and my sound (in&out) was always juttery //intemittent, was fine on my old much worse PC.
I'd then start up the Gamefirst app, set vent to highest and it'd really help.
However... I found just disabling he gamefirst service from startup meant that vent worked fine from the get go, and all my other internet traffic was absolutely fine.