Which VM software (and version)?
I never trust VMs running inside Windows, lol, unless the WinOS itself is running in a VM.
You can try your VM configuration in a linux, lots of them will boot from "Live USB" so you don't even have to do a fixed drive install.
I assume you've installed the chipset (X99 and ASMedia) drivers from the ASUS R5E page? You might also try upflashing to latest R5E BIOS, if you haven't already.
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[/Korth]