Chino is right in that the two black USB ports on the top of the case are USB2.0, and the two blue ones are USB3.0. These ports have internal cables attached to them which you need to plug into the appropriate headers on the motherboard. For the R5E the USB2.0 headers are on the bottom right edge as shown in this image from the manual:
there is one labeled USB1314 and the other one is labeled USB1112. The latter is not available if you attach the ROG_EXT cable to the OC Panel or Front Base. That takes care of the black USB2.0 ports on the case. For the blue USB3.0 ports on the case, you can plug their cable into either USB3_34 on the bottom edge, or into USB3_12 on the right edge just below the 24-pin power connector as shown in this image
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Often a USB2.0 device will work on a USB3.0 port, but at the lower speed. If it still doesn't work, in the UEFI BIOS setting "USB Configuration", see that "EHCI Legacy Support" is set at its default value of "Enabled", or at "Auto" to get support for USB 2.0 devices. I hope this is all you need, good luck.
there is one labeled USB1314 and the other one is labeled USB1112. The latter is not available if you attach the ROG_EXT cable to the OC Panel or Front Base. That takes care of the black USB2.0 ports on the case. For the blue USB3.0 ports on the case, you can plug their cable into either USB3_34 on the bottom edge, or into USB3_12 on the right edge just below the 24-pin power connector as shown in this image
. Often a USB2.0 device will work on a USB3.0 port, but at the lower speed. If it still doesn't work, in the UEFI BIOS setting "USB Configuration", see that "EHCI Legacy Support" is set at its default value of "Enabled", or at "Auto" to get support for USB 2.0 devices. I hope this is all you need, good luck.
