The last time I used AMD was an Athlon 64, since then I've been Intel.
I knew the potential risks by going with AMD on this upgrade and to be honest, I haven't encountered anything major at all. In fact, I feel that I've spent my money wisely as I have an AMD system that destroys anything Intel can offer in this price range.
The only issues for me were USB, fan control and memory compatibility. The fan control is fixed for me in BIOS 0012, memory has been running stable at 3200 as well but for USB I had to get another USB hub (my Pixel XL was not charging).
That aside, my PC is stable running applications or games, both of which perform well - and that's what matters the most for me.