SupremeFX has been a staple addition to Republic of Gamers motherboards ever since the very first Crosshair. Its design is focused on improving sound quality beyond the standard that most motherboards included, by putting the audio onto a separate sound card that plugged into a PCIe x1 slot. Isolating the analogue sounds in this way helped improve audio quality.
In the intervening 5 years, SupremeFX has evolved into its third revision. First added to the Rampage IV Series late last year, it's now following onto the Maximus V GENE as well.